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Ancho Chile Pork Tenderloin with Brussels Sprouts and Squash

A flavorful roasted pork tenderloin seasoned with ancho chile and cumin, served alongside caramelized brussels sprouts, delicata squash, and red onion. Finished with a creamy cilantro-lime sauce for a delicious Mexican-inspired meal.

6 servings
55 min
Published October 4, 2025
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Ingredients

  • •2 whole limes
  • •2 teaspoons ground cumin
  • •1 teaspoon ancho chile powder
  • •1 teaspoon brown sugar
  • •2¼ teaspoons kosher salt
  • •2 pounds pork tenderloins
  • •1½ pounds brussels sprouts
  • •1 whole red onion
  • •1 whole delicata squash
  • •4 tablespoons vegetable oil
  • •¾ cup sour cream
  • •½ cup cilantro
  • •to taste flaky sea salt and black pepper

Cooking Instructions

  1. 1.

    Place racks in top and center of oven; preheat to 425°F. Finely grate 2 tsp. lime zest into a small bowl. Stir in cumin, chile powder, brown sugar, and 2 tsp. salt.

    5 min

  2. 2.

    Toss brussels sprouts, onion, squash, 2 Tbsp. oil, and half of spiced salt on a rimmed baking sheet. Transfer to center rack in oven and roast 10 minutes. Toss and continue to roast until vegetables are browned and cooked through, 10-15 minutes more.

    25 min

  3. 3.

    Meanwhile, rub pork tenderloins with remaining spiced salt and heat remaining 2 Tbsp. oil in a large skillet over medium-high. Sear pork on 3 sides until lightly browned, about 3 minutes per side. Turn tenderloins onto remaining side, then transfer skillet to top rack of oven. Roast pork until an instant-read thermometer inserted into thickest part registers 140°F for medium-rare or 145°F for medium, 8-10 minutes (temperature will rise by about 10°F after cooking). Transfer pork to a cutting board and let rest 5 minutes before slicing.

    20 min

  4. 4.

    Whisk sour cream, 2 tsp. lime juice, 1/2 cup cilantro, and remaining 1/4 tsp. salt in a small bowl. Spoon some sauce onto plates, then arrange pork over. Top with cilantro leaves, flakey sea salt, and pepper. Serve vegetables and lime wedges alongside.

    5 min

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Language: English
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